ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

KCNS1

Full Name:

potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1

Alias:

KV9.1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

20q12

Physical Location:

43154363-43163166 on NC_000020.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D20S119

43082264

Region:		41082264-45082264
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002251.3	NP_002242.2	NC_000020.9 range: 43154363..43163166, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IDA (10484328)
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IDA (10484328)
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0015459	potassium channel regulator activity	Molecular Function	IDA (10484328)
GO:0030955	potassium ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10484328)
GO:0005251	delayed rectifier potassium channel activity	Molecular Function	IDA (10484328)
GO:0006811	ion transport	Biological Process	IEA
GO:0006813	potassium ion transport	Biological Process	TAS (10484328)