ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

KRT6A

Full Name:

keratin 6A

Alias:

CK6A|CK6C|CK6D|K6A|K6C|K6D|KRT6C|KRT6D

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12q12-q13

Physical Location:

51167224-51173447 on NC_000012.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 16687 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		L42611
Fold Change:		-1.6, -2.8
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005554.3	NP_005545.1	NC_000012.10 range: 51167224..51173447, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0005882	intermediate filament	Cellular Component	TAS (2410904)
GO:0005200	structural constituent of cytoskeleton	Molecular Function	NAS (7543104)
GO:0005515	protein binding	Molecular Function	IPI (16189514)
GO:0007398	ectoderm development	Biological Process	TAS (7545493)
GO:0008284	positive regulation of cell proliferation	Biological Process	NAS (7543104)
GO:0030154	cell differentiation	Biological Process	NAS (7543104)