ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ARHGAP5

Full Name:

Rho GTPase activating protein 5

Alias:

GFI2|RhoGAP5|p190-B

Organism:

Homo sapiens (Human)

Chromosome:

14

Genetic Location:

14q12

Physical Location:

31616245-31698684 on NC_000014.7

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D14S70

33528945

Region:		31528945-35528945
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001030055.1	NP_001025226.1	NC_000014.7 range: 31616245..31698684
NM_001173.2	NP_001164.2	NC_000014.7 range: 31616245..31698684

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	TAS (8537347)
GO:0016020	membrane	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0005100	Rho GTPase activator activity	Molecular Function	TAS (8537347)
GO:0005096	GTPase activator activity	Molecular Function	IEA
GO:0003924	GTPase activity	Molecular Function	TAS (8537347)
GO:0042169	SH2 domain binding	Molecular Function	IPI (1689011)
GO:0007155	cell adhesion	Biological Process	TAS (8537347)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0007266	Rho protein signal transduction	Biological Process	TAS (8537347)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000100852

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: