ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

LDLR

Full Name:

low density lipoprotein receptor (familial hypercholesterolemia)

Alias:

FH|FHC

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

19p13.3

Physical Location:

11061131-11105489 on NC_000019.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

LDLR

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000527.3	NP_000518.1	NC_000019.8 range: 11061131..11105489

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0010008	endosome membrane	Cellular Component	EXP (221835)
GO:0016020	membrane	Cellular Component	IEA
GO:0030669	clathrin-coated endocytic vesicle membrane	Cellular Component	EXP (221835)
GO:0005905	coated pit	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (6327078)
GO:0005886	plasma membrane	Cellular Component	TAS (2777800)
GO:0005886	plasma membrane	Cellular Component	EXP (221835\|8300609)
GO:0004888	transmembrane receptor activity	Molecular Function	TAS (6091915)
GO:0008034	lipoprotein binding	Molecular Function	TAS (6091915)
GO:0030229	very-low-density lipoprotein receptor activity	Molecular Function	IDA (8626535)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005041	low-density lipoprotein receptor activity	Molecular Function	TAS (2777800)
GO:0005319	lipid transporter activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0030301	cholesterol transport	Biological Process	IMP (17142622)
GO:0030299	cholesterol absorption	Biological Process	IMP (17142622)
GO:0008203	cholesterol metabolic process	Biological Process	IEA
GO:0008202	steroid metabolic process	Biological Process	IEA
GO:0006897	endocytosis	Biological Process	TAS (12671190)
GO:0006869	lipid transport	Biological Process	IEA
GO:0006629	lipid metabolic process	Biological Process	TAS (6299582\|10827173)
GO:0006493	protein amino acid O-linked glycosylation	Biological Process	TAS (6091915)
GO:0042157	lipoprotein metabolic process	Biological Process	IMP (17142622)