ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

LIF

Full Name:

leukemia inhibitory factor (cholinergic differentiation factor)

Alias:

CDF|D-FACTOR|HILDA

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

22q12.2

Physical Location:

28966440-28972747 on NC_000022.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

LIF

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002309.2	NP_002300.1	NC_000022.9 range: 28966440..28972747, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IEA
GO:0005125	cytokine activity	Molecular Function	IDA (7957045)
GO:0005146	leukemia inhibitory factor receptor binding	Molecular Function	IDA (7957045)
GO:0005147	oncostatin-M receptor binding	Molecular Function	NR
GO:0008083	growth factor activity	Molecular Function	IDA (7957045)
GO:0043410	positive regulation of MAPKKK cascade	Biological Process	IDA (7508917)
GO:0045651	positive regulation of macrophage differentiation	Biological Process	IDA (7957045)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA (7508917)
GO:0046888	negative regulation of hormone secretion	Biological Process	IDA (7867561)
GO:0033138	positive regulation of peptidyl-serine phosphorylation	Biological Process	IDA (7508917)
GO:0008284	positive regulation of cell proliferation	Biological Process	IDA (7957045)
GO:0007275	multicellular organismal development	Biological Process	TAS (3143918)
GO:0007267	cell-cell signaling	Biological Process	NR
GO:0007166	cell surface receptor linked signal transduction	Biological Process	NR
GO:0006955	immune response	Biological Process	IEA
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Biological Process	IDA (7508917)