Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:3976
Symbol:LIF
Full Name:leukemia inhibitory factor (cholinergic differentiation factor)
Alias:CDF|D-FACTOR|HILDA
Organism:Homo sapiens (Human)
Chromosome:22
Genetic Location:22q12.2
Physical Location:28966440-28972747 on NC_000022.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:LIF
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002309.2NP_002300.1NC_000022.9 range: 28966440..28972747, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentIEA
GO:0005125cytokine activityMolecular FunctionIDA (7957045)
GO:0005146leukemia inhibitory factor receptor bindingMolecular FunctionIDA (7957045)
GO:0005147oncostatin-M receptor bindingMolecular FunctionNR
GO:0008083growth factor activityMolecular FunctionIDA (7957045)
GO:0043410positive regulation of MAPKKK cascadeBiological ProcessIDA (7508917)
GO:0045651positive regulation of macrophage differentiationBiological ProcessIDA (7957045)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (7508917)
GO:0046888negative regulation of hormone secretionBiological ProcessIDA (7867561)
GO:0033138positive regulation of peptidyl-serine phosphorylationBiological ProcessIDA (7508917)
GO:0008284positive regulation of cell proliferationBiological ProcessIDA (7957045)
GO:0007275multicellular organismal developmentBiological ProcessTAS (3143918)
GO:0007267cell-cell signalingBiological ProcessNR
GO:0007166cell surface receptor linked signal transductionBiological ProcessNR
GO:0006955immune responseBiological ProcessIEA
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationBiological ProcessIDA (7508917)
Other Database Cross Links
NCBI Entrez Gene:3976
HGNC:6596
Ensembl:ENSG00000128342
MIM:159540
HPRD:08869
HuGE Navigator:3976
dbSNP:LIF
GeneCard:LIF
AceView:LIF