ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

3981

Symbol:

LIG4

Full Name:

ligase IV, DNA, ATP-dependent

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

13q33-q34

Physical Location:

107657790-107668716 on NC_000013.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D13S1265

108126458

Region:		106126458-110126458
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001098268.1	NP_001091738.1	NC_000013.9 range: 107657790..107668716, complement
NM_002312.3	NP_002303.2	NC_000013.9 range: 107657790..107668716, complement
NM_206937.1	NP_996820.1	NC_000013.9 range: 107657790..107668716, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0032807	DNA ligase IV complex	Cellular Component	IMP (9809069)
GO:0005958	DNA-dependent protein kinase complex	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IDA (8798671\|12589063)
GO:0005622	intracellular	Cellular Component	IEA
GO:0000793	condensed chromosome	Cellular Component	IDA (12589063)
GO:0032807	DNA ligase IV complex	Cellular Component	IPI (9242410)
GO:0016874	ligase activity	Molecular Function	IDA (9242410)
GO:0008022	protein C-terminus binding	Molecular Function	IPI (12589063)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IC (8798671)
GO:0003910	DNA ligase (ATP) activity	Molecular Function	IDA (8798671)
GO:0003677	DNA binding	Molecular Function	IDA (8798671)
GO:0033077	T cell differentiation in the thymus	Biological Process	ISS
GO:0033153	T cell receptor V(D)J recombination	Biological Process	ISS
GO:0035019	somatic stem cell maintenance	Biological Process	ISS
GO:0043524	negative regulation of neuron apoptosis	Biological Process	ISS
GO:0045190	isotype switching	Biological Process	ISS
GO:0048146	positive regulation of fibroblast proliferation	Biological Process	ISS
GO:0050769	positive regulation of neurogenesis	Biological Process	ISS
GO:0051102	DNA ligation during DNA recombination	Biological Process	ISS
GO:0051103	DNA ligation during DNA repair	Biological Process	IDA (12517771)
GO:0051103	DNA ligation during DNA repair	Biological Process	ISS
GO:0051276	chromosome organization and biogenesis	Biological Process	ISS
GO:0000012	single strand break repair	Biological Process	IDA (8798671)
GO:0019059	initiation of viral infection	Biological Process	EXP (12091904)
GO:0001701	in utero embryonic development	Biological Process	ISS
GO:0002328	pro-B cell differentiation	Biological Process	ISS
GO:0006260	DNA replication	Biological Process	IEA
GO:0006297	nucleotide-excision repair, DNA gap filling	Biological Process	IDA (12517771)
GO:0006303	double-strand break repair via nonhomologous end joining	Biological Process	IDA (12517771)
GO:0006303	double-strand break repair via nonhomologous end joining	Biological Process	IMP (9809069)
GO:0007049	cell cycle	Biological Process	IEA
GO:0007417	central nervous system development	Biological Process	ISS
GO:0008283	cell proliferation	Biological Process	ISS
GO:0010165	response to X-ray	Biological Process	IMP (9809069)
GO:0010332	response to gamma radiation	Biological Process	ISS
GO:0019047	provirus integration	Biological Process	EXP (16291214)
GO:0051301	cell division	Biological Process	IEA