ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Scn4b

Full Name:

sodium channel, type IV, beta

Alias:

Gm1471

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 A5.2

Physical Location:

44947124-44962143 on NC_000075.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6330 Symbol (Name): SCN4B (sodium channel, voltage-gated, type IV, beta)

Ortholog Status:

The human GeneID 6330 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Scn4b

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001013390.2	NP_001013408.1	NC_000075.5 range: 44947124..44962143

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0005272	sodium channel activity	Molecular Function	IEA
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006814	sodium ion transport	Biological Process	IEA