ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

LLGL1

Full Name:

lethal giant larvae homolog 1 (Drosophila)

Alias:

DLG4|HUGL|HUGL-1|HUGL1|LLGL

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17p11.2

Physical Location:

18069660-18088913 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 16897 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S1857

16355942

Region:		14355942-18355942
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004140.3	NP_004131.3	NC_000017.9 range: 18069660..18088913

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (7542763)
GO:0005856	cytoskeleton	Cellular Component	TAS (7542763)
GO:0030864	cortical actin cytoskeleton	Cellular Component	IDA (7542763)
GO:0005198	structural molecule activity	Molecular Function	TAS (7542763)
GO:0005515	protein binding	Molecular Function	IPI (7542763)
GO:0019901	protein kinase binding	Molecular Function	IDA (7542763)
GO:0006461	protein complex assembly	Biological Process	IDA (7542763)
GO:0030866	cortical actin cytoskeleton organization and biogenesis	Biological Process	IDA (7542763)