ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

LTA

Full Name:

lymphotoxin alpha (TNF superfamily, member 1)

Alias:

LT|TNFB|TNFSF1

Organism:

Homo sapiens (Human)

Chromosome:

6

Genetic Location:

6p21.3

Physical Location:

31648071-31650076 on NC_000006.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

LTA

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Original ID	No. of Publications	Phenotype
LTA	1	Alcoholism
LTA	1	Alcohol-Related Disorders

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000595.2	NP_000586.2	NC_000006.10 range: 31648071..31650076

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	IEA
GO:0004197	cysteine-type endopeptidase activity	Molecular Function	IEA
GO:0005164	tumor necrosis factor receptor binding	Molecular Function	IEA
GO:0005125	cytokine activity	Molecular Function	IEA
GO:0006917	induction of apoptosis	Biological Process	TAS (6334807)
GO:0006955	immune response	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	TAS (6334807)
GO:0007267	cell-cell signaling	Biological Process	TAS (6334807)
GO:0006508	proteolysis	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000204496

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: