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Gene Information
Gene ID:4049
Symbol:LTA
Full Name:lymphotoxin alpha (TNF superfamily, member 1)
Alias:LT|TNFB|TNFSF1
Organism:Homo sapiens (Human)
Chromosome:6
Genetic Location:6p21.3
Physical Location:31648071-31650076 on NC_000006.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:LTA
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
LTA1Alcoholism
LTA1Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000595.2NP_000586.2NC_000006.10 range: 31648071..31650076
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentIEA
GO:0005576extracellular regionCellular ComponentIEA
GO:0004197cysteine-type endopeptidase activityMolecular FunctionIEA
GO:0005164tumor necrosis factor receptor bindingMolecular FunctionIEA
GO:0005125cytokine activityMolecular FunctionIEA
GO:0006917induction of apoptosisBiological ProcessTAS (6334807)
GO:0006955immune responseBiological ProcessIEA
GO:0007165signal transductionBiological ProcessTAS (6334807)
GO:0007267cell-cell signalingBiological ProcessTAS (6334807)
GO:0006508proteolysisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:4049
HGNC:6709
Ensembl:ENSG00000204496
MIM:153440
HPRD:01084
HuGE Navigator:4049
dbSNP:LTA
GeneCard:LTA
AceView:LTA