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Gene Information
Gene ID:4088
Symbol:SMAD3
Full Name:SMAD family member 3
Alias:DKFZP586N0721|DKFZp686J10186|HSPC193|HsT17436|JV15-2|MADH3|MGC60396|Smad 3
Organism:Homo sapiens (Human)
Chromosome:15
Genetic Location:15q22.33
Physical Location:65145248-65274586 on NC_000015.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:SMAD3
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_005902.3NP_005893.1NC_000015.8 range: 65145248..65274586
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (9311995|9865696|11100470)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005667transcription factor complexCellular ComponentIEA
GO:0005654nucleoplasmCellular ComponentEXP (10549282)
GO:0005634nucleusCellular ComponentIEA
GO:0005622intracellularCellular ComponentIC (14612439)
GO:0043235receptor complexCellular ComponentIMP (8774881)
GO:0042803protein homodimerization activityMolecular FunctionIPI (8774881)
GO:0015460transport accessory protein activityMolecular FunctionIDA (15799969)
GO:0043565sequence-specific DNA bindingMolecular FunctionIDA (10823886)
GO:0046332SMAD bindingMolecular FunctionIPI (8774881)
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0045930negative regulation of mitotic cell cycleBiological ProcessIMP (14555988)
GO:0042993positive regulation of transcription factor import into nucleusBiological ProcessIDA (15799969)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (8774881)
GO:0032909regulation of transforming growth factor-beta2 productionBiological ProcessIMP (12411310)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessIMP (14555988)
GO:0030308negative regulation of cell growthBiological ProcessIDA (8774881)
GO:0019049evasion of host defenses by virusBiological ProcessIDA (15334054)
GO:0017015regulation of transforming growth factor beta receptor signaling pathwayBiological ProcessIMP (8774881)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessIMP (14555988)
GO:0001666response to hypoxiaBiological ProcessIMP (12411310)
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006917induction of apoptosisBiological ProcessIMP (15334054)
GO:0006919caspase activationBiological ProcessIMP (15107418)
GO:0007050cell cycle arrestBiological ProcessIMP (14555988)
GO:0007183SMAD protein complex assemblyBiological ProcessIDA (10823886)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessIDA (8774881)
Other Database Cross Links
NCBI Entrez Gene:4088
HGNC:6769
Ensembl:ENSG00000166949
MIM:603109
HPRD:04380
HuGE Navigator:4088
dbSNP:SMAD3
GeneCard:SMAD3
AceView:SMAD3