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Gene Information
Gene ID:4089
Symbol:SMAD4
Full Name:SMAD family member 4
Alias:DPC4|JIP|MADH4
Organism:Homo sapiens (Human)
Chromosome:18
Genetic Location:18q21.1
Physical Location:46810610-46860144 on NC_000018.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:SMAD4
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_005359.4NP_005350.1NC_000018.8 range: 46810610..46860144
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005622intracellularCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0005654nucleoplasmCellular ComponentEXP (10549282|11121043)
GO:0005667transcription factor complexCellular ComponentIPI (12374795)
GO:0005829cytosolCellular ComponentEXP (9311995)
GO:0042803protein homodimerization activityMolecular FunctionIPI (8774881)
GO:0043565sequence-specific DNA bindingMolecular FunctionIDA (10823886)
GO:0046332SMAD bindingMolecular FunctionIPI (8774881)
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0045893positive regulation of transcription, DNA-dependentBiological ProcessIDA (8774881)
GO:0045892negative regulation of transcription, DNA-dependentBiological ProcessIDA (8774881)
GO:0032909regulation of transforming growth factor-beta2 productionBiological ProcessIMP (12411310)
GO:0030509BMP signaling pathwayBiological ProcessEXP (15621726)
GO:0030308negative regulation of cell growthBiological ProcessIDA (8774881)
GO:0017015regulation of transforming growth factor beta receptor signaling pathwayBiological ProcessIMP (8774881)
GO:0007183SMAD protein complex assemblyBiological ProcessIDA (10823886)
GO:0006350transcriptionBiological ProcessIEA
GO:0001666response to hypoxiaBiological ProcessIMP (12411310)
Other Database Cross Links
NCBI Entrez Gene:4089
HGNC:6770
Ensembl:ENSG00000141646
MIM:600993
HPRD:02995
HuGE Navigator:4089
dbSNP:SMAD4
GeneCard:SMAD4
AceView:SMAD4