ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SMAD4

Full Name:

SMAD family member 4

Alias:

DPC4|JIP|MADH4

Organism:

Homo sapiens (Human)

Chromosome:

18

Genetic Location:

18q21.1

Physical Location:

46810610-46860144 on NC_000018.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

SMAD4

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005359.4	NP_005350.1	NC_000018.8 range: 46810610..46860144

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0005654	nucleoplasm	Cellular Component	EXP (10549282\|11121043)
GO:0005667	transcription factor complex	Cellular Component	IPI (12374795)
GO:0005829	cytosol	Cellular Component	EXP (9311995)
GO:0042803	protein homodimerization activity	Molecular Function	IPI (8774881)
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (10823886)
GO:0046332	SMAD binding	Molecular Function	IPI (8774881)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA (8774881)
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA (8774881)
GO:0032909	regulation of transforming growth factor-beta2 production	Biological Process	IMP (12411310)
GO:0030509	BMP signaling pathway	Biological Process	EXP (15621726)
GO:0030308	negative regulation of cell growth	Biological Process	IDA (8774881)
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	Biological Process	IMP (8774881)
GO:0007183	SMAD protein complex assembly	Biological Process	IDA (10823886)
GO:0006350	transcription	Biological Process	IEA
GO:0001666	response to hypoxia	Biological Process	IMP (12411310)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000141646

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: