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Gene Information
Gene ID:4093
Symbol:SMAD9
Full Name:SMAD family member 9
Alias:MADH6|MADH9|SMAD8A|SMAD8B
Organism:Homo sapiens (Human)
Chromosome:13
Genetic Location:13q12-q14
Physical Location:36320320-36351965 on NC_000013.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D13S171  32151912
Region:32151912-40979230
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_005905.4NP_005896.1NC_000013.9 range: 36320320..36351965, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005829cytosolCellular ComponentEXP (9436979|17356069)
GO:0005622intracellularCellular ComponentTAS (9256479)
GO:0005634nucleusCellular ComponentIEA
GO:0005654nucleoplasmCellular ComponentEXP (11121043)
GO:0005667transcription factor complexCellular ComponentIEA
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0007179transforming growth factor beta receptor signaling pathwayBiological ProcessIEA
GO:0030509BMP signaling pathwayBiological ProcessEXP (15621726)
Other Database Cross Links
NCBI Entrez Gene:4093
HGNC:6774
Ensembl:ENSG00000120693
MIM:603295
HPRD:
HuGE Navigator:4093
dbSNP:SMAD9
GeneCard:SMAD9
AceView:SMAD9