| Gene Information |
| Gene ID: | | 4124 |
| Symbol: | | MAN2A1 |
| Full Name: | | mannosidase, alpha, class 2A, member 1 |
| Alias: | | GOLIM7|MANA2|MANII |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 5 |
| Genetic Location: | | 5q21-q22 |
| Physical Location: | | 109053054-109231327 on NC_000005.8 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | AA115560 | | Fold Change: | | 0.67 | | P Value: | | 9.00E-04 | | Tissue: | | Nucleus accumbens |
| | Dataset Information | | Name: | | 15816859 | | Method: | | Microarray | | Tissue: | | Prefrontal cortex and nucleus accumbens | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed | | Summary: | | Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0000139 | Golgi membrane | Cellular Component | IEA | |
| GO:0016021 | integral to membrane | Cellular Component | IEA | |
| GO:0005624 | membrane fraction | Cellular Component | NR | |
| GO:0005794 | Golgi apparatus | Cellular Component | IEA | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0030246 | carbohydrate binding | Molecular Function | IEA | |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | Molecular Function | IEA | |
| GO:0015923 | mannosidase activity | Molecular Function | IEA | |
| GO:0008270 | zinc ion binding | Molecular Function | IEA | |
| GO:0046872 | metal ion binding | Molecular Function | IEA | |
| GO:0004572 | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity | Molecular Function | TAS (8524845) | |
| GO:0004559 | alpha-mannosidase activity | Molecular Function | IEA | |
| GO:0003824 | catalytic activity | Molecular Function | IEA | |
| GO:0009101 | glycoprotein biosynthetic process | Biological Process | NR | |
| GO:0006013 | mannose metabolic process | Biological Process | IEA | |
| GO:0005975 | carbohydrate metabolic process | Biological Process | IEA | |
| GO:0008152 | metabolic process | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 4124 |
| HGNC: | | 6824 |
| Ensembl: | | ENSG00000112893 |
| MIM: | | 154582 |
| HPRD: | | 01110 |
| HuGE Navigator: | | 4124 |
| dbSNP: | | MAN2A1 |
| GeneCard: | | MAN2A1 |
| AceView: | | MAN2A1 |
