ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MAP2

Full Name:

microtubule-associated protein 2

Alias:

DKFZp686I2148|MAP2A|MAP2B|MAP2C

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q34-q35

Physical Location:

209997015-210307078 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 17756 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

MAP2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005874	microtubule	Cellular Component	IEA
GO:0005875	microtubule associated complex	Cellular Component	TAS (9588626)
GO:0005875	microtubule associated complex	Cellular Component	NAS (7854050)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0003674	molecular_function	Molecular Function	ND
GO:0005516	calmodulin binding	Molecular Function	IEA
GO:0005198	structural molecule activity	Molecular Function	NAS (9588626)
GO:0007026	negative regulation of microtubule depolymerization	Biological Process	IEA
GO:0008150	biological_process	Biological Process	ND