ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

4137

Symbol:

MAPT

Full Name:

microtubule-associated protein tau

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q21.1

Physical Location:

41327623-41461546 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		BM725941
Fold Change:		1.71
P Value:		0.04
Tissue:		Prefrontal cortex

Gene Information

Original ID1:		BM725941
Fold Change:		1.57
P Value:		0.05
Tissue:		Nucleus accumbens

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005910.4	NP_005901.2	NC_000017.9 range: 41327623..41461546
NM_016834.3	NP_058518.1	NC_000017.9 range: 41327623..41461546
NM_016835.3	NP_058519.2	NC_000017.9 range: 41327623..41461546
NM_016841.3	NP_058525.1	NC_000017.9 range: 41327623..41461546

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045298	tubulin complex	Cellular Component	ISS
GO:0030424	axon	Cellular Component	IDA (8642405)
GO:0030424	axon	Cellular Component	ISS
GO:0030426	growth cone	Cellular Component	IDA (8642405)
GO:0030426	growth cone	Cellular Component	ISS
GO:0005886	plasma membrane	Cellular Component	ISS
GO:0005886	plasma membrane	Cellular Component	IDA (8522593)
GO:0005875	microtubule associated complex	Cellular Component	TAS (10747907)
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	TAS (10747907)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0045298	tubulin complex	Cellular Component	IDA (8642405)
GO:0042995	cell projection	Cellular Component	IEA
GO:0019899	enzyme binding	Molecular Function	IPI (9736630\|12888622)
GO:0017124	SH3 domain binding	Molecular Function	IPI (9763511)
GO:0008034	lipoprotein binding	Molecular Function	IPI (7972031)
GO:0008017	microtubule binding	Molecular Function	ISS
GO:0008017	microtubule binding	Molecular Function	IDA (1918161)
GO:0005200	structural constituent of cytoskeleton	Molecular Function	TAS (2498079)
GO:0034187	apolipoprotein E binding	Molecular Function	IPI (7566652)
GO:0045773	positive regulation of axon extension	Biological Process	IDA (1389180)
GO:0045773	positive regulation of axon extension	Biological Process	ISS
GO:0031116	positive regulation of microtubule polymerization	Biological Process	ISS
GO:0031116	positive regulation of microtubule polymerization	Biological Process	IDA (1421571)
GO:0000226	microtubule cytoskeleton organization and biogenesis	Biological Process	IDA (1057175)
GO:0007026	negative regulation of microtubule depolymerization	Biological Process	IEA
GO:0000226	microtubule cytoskeleton organization and biogenesis	Biological Process	ISS
GO:0048699	generation of neurons	Biological Process	NAS (8522593)