ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MDK

Full Name:

midkine (neurite growth-promoting factor 2)

Alias:

FLJ27379|MK|NEGF2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

11p11.2

Physical Location:

46359193-46361950 on NC_000011.8

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 17242 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	NR
GO:0005125	cytokine activity	Molecular Function	NR
GO:0008201	heparin binding	Molecular Function	IDA (9384573)
GO:0008083	growth factor activity	Molecular Function	NAS (1639750)
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0007399	nervous system development	Biological Process	NAS (9384573)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007267	cell-cell signaling	Biological Process	NR
GO:0007165	signal transduction	Biological Process	NAS (7835084)
GO:0008283	cell proliferation	Biological Process	IEA
GO:0009611	response to wounding	Biological Process	ISS
GO:0030154	cell differentiation	Biological Process	NAS (1639750)
GO:0030325	adrenal gland development	Biological Process	ISS