ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ME1

Full Name:

malic enzyme 1, NADP(+)-dependent, cytosolic

Alias:

HUMNDME|MES

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6q12

Physical Location:

83976826-84197497 on NC_000006.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Fly: 47173 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

ME1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002395.3	NP_002386.1	NC_000006.10 range: 83976826..84197497, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	ISS
GO:0004473	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity	Molecular Function	IDA (8187880)
GO:0050661	NADP binding	Molecular Function	TAS (7622060)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0043531	ADP binding	Molecular Function	TAS (7622060)
GO:0030145	manganese ion binding	Molecular Function	IDA (7622060)
GO:0009055	electron carrier activity	Molecular Function	TAS (7622060)
GO:0051287	NAD binding	Molecular Function	TAS (7622060)
GO:0005488	binding	Molecular Function	IEA
GO:0004473	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity	Molecular Function	ISS
GO:0006741	NADP biosynthetic process	Biological Process	TAS (8187880)
GO:0009725	response to hormone stimulus	Biological Process	ISS
GO:0009743	response to carbohydrate stimulus	Biological Process	TAS (8187880)
GO:0006108	malate metabolic process	Biological Process	IDA (7622060\|8187880)
GO:0005975	carbohydrate metabolic process	Biological Process	NAS (8187880)
GO:0008152	metabolic process	Biological Process	IEA