ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MGST3

Full Name:

microsomal glutathione S-transferase 3

Alias:

GST-III

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q23

Physical Location:

163867073-163891480 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 66447 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D1S2878

163669990

Region:		163669990-165871089
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004528.2	NP_004519.1	NC_000001.9 range: 163867073..163891480

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005792	microsome	Cellular Component	TAS (9278457)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	TAS (9278457)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0004364	glutathione transferase activity	Molecular Function	TAS (9278457)
GO:0004601	peroxidase activity	Molecular Function	TAS (9278457)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006629	lipid metabolic process	Biological Process	TAS (9278457)
GO:0007165	signal transduction	Biological Process	TAS (9278457)