ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MME

Full Name:

membrane metallo-endopeptidase

Alias:

CALLA|CD10|DKFZp686O16152|MGC126681|MGC126707|NEP

Organism:

Homo sapiens (Human)

Chromosome:

3

Genetic Location:

3q25.1-q25.2

Physical Location:

156280129-156384211 on NC_000003.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

MME

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Original ID	No. of Publications	Phenotype
MME	1	Alcoholism

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000902.3	NP_000893.2	NC_000003.10 range: 156280129..156384211
NM_007287.2	NP_009218.2	NC_000003.10 range: 156280129..156384211
NM_007288.2	NP_009219.2	NC_000003.10 range: 156280129..156384211
NM_007289.2	NP_009220.2	NC_000003.10 range: 156280129..156384211

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	TAS (1660144)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (2521388)
GO:0004245	neprilysin activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008237	metallopeptidase activity	Molecular Function	TAS (1660144)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17220478\|17342744)
GO:0007267	cell-cell signaling	Biological Process	TAS (2521388)
GO:0006508	proteolysis	Biological Process	IEA
GO:0006508	proteolysis	Biological Process	TAS (1660144)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000196549

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: