ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MMP3

Full Name:

matrix metallopeptidase 3 (stromelysin 1, progelatinase)

Alias:

MGC126102|MGC126103|MGC126104|MMP-3|SL-1|STMY|STMY1|STR1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

11q22.3

Physical Location:

102211737-102219551 on NC_000011.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

MMP3

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Original ID	No. of Publications	Phenotype
MMP3	1	Alcoholism

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002422.3	NP_002413.1	NC_000011.8 range: 102211737..102219551, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	TAS (3360803)
GO:0004248	stromelysin 1 activity	Molecular Function	TAS (3360803)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0006508	proteolysis	Biological Process	TAS (3360803)
GO:0008152	metabolic process	Biological Process	IEA
GO:0030574	collagen catabolic process	Biological Process	IEA