ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MMP9

Full Name:

matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Alias:

CLG4B|GELB|MMP-9

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

20q11.2-q13.1

Physical Location:

44070953-44078606 on NC_000020.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

MMP9

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D20S119

43082264

Region:		41082264-45082264
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004994.2	NP_004985.2	NC_000020.9 range: 44070953..44078606

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IDA (2251898)
GO:0004229	gelatinase B activity	Molecular Function	IDA (16192646)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0005518	collagen binding	Molecular Function	TAS (2251898)
GO:0008133	collagenase activity	Molecular Function	IDA (2551898)
GO:0008270	zinc ion binding	Molecular Function	TAS (2251898)
GO:0030225	macrophage differentiation	Biological Process	TAS (2251898)
GO:0008152	metabolic process	Biological Process	IEA
GO:0006508	proteolysis	Biological Process	IDA (2551898)
GO:0030574	collagen catabolic process	Biological Process	IEA