Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:441208
Symbol:LOC441208
Organism:Homo sapiens (Human)
Chromosome:7
Genetic Location:7p14.3
Physical Location:32734266-32736119 on NC_000007.12
Gene Type:pseudo
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene SNP Information
SNPAbuser/Control RatioCluster
rs2391802      dbSNP1.2129
Association Dataset
Name:16894614
Method:Association
Publication:Johnson et al. Am J Med Genet B Neuropsychiatr Genet. (2006) Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. PubMed
Summary:Association genome scanning can identify markers for the allelic variants that contribute to vulnerability to complex disorders, including alcohol dependence. To improve the power and feasibility of this approach, we report validation of 100k microarray-based allelic frequency assessments in pooled DNA samples. We then use this approach with unrelated alcohol-dependent versus control individuals sampled from pedigrees collected by the Collaborative Study on the Genetics of Alcoholism (COGA). Allele frequency differences between alcohol-dependent and control individuals are assessed in quadruplicate at 104,268 autosomal SNPs in pooled samples. One hundred eighty-eight SNPs provide (1) the largest allele frequency differences between dependent versus control individuals; (2) t values 3 for these differences; and (3) clustering, so that 51 relatively small chromosomal regions contain at least three SNPs that satisfy criteria 1 and 2 above (Monte Carlo P = 0.00034).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NR_003502.1-NC_000007.12 range: 32734266..32736119
Other Database Cross Links
NCBI Entrez Gene:441208
HGNC:
Ensembl:
MIM:
HPRD:18648
HuGE Navigator:441208
dbSNP:LOC441208
GeneCard:LOC441208
AceView:LOC441208