ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MSRA

Full Name:

methionine sulfoxide reductase A

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8p23.1

Physical Location:

9949235-10323804 on NC_000008.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 110265 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D8S550

10918926

Region:		8918926-12918926
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012331.2	NP_036463.1	NC_000008.9 range: 9949235..10323804

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0008113	peptide-methionine-(S)-S-oxide reductase activity	Molecular Function	TAS (10452521)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0016671	oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor	Molecular Function	IEA
GO:0006464	protein modification process	Biological Process	TAS (10452521)
GO:0006555	methionine metabolic process	Biological Process	TAS (10452521)
GO:0006979	response to oxidative stress	Biological Process	TAS (10452521)
GO:0019538	protein metabolic process	Biological Process	IEA