ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MTHFD1

Full Name:

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

Alias:

MTHFC|MTHFD

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

14q24

Physical Location:

63924845-63996473 on NC_000014.7

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

MTHFD1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005956.2	NP_005947.2	NC_000014.7 range: 63924845..63996473

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	TAS (3528153)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	Molecular Function	IEA
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	Molecular Function	TAS (3053686)
GO:0004329	formate-tetrahydrofolate ligase activity	Molecular Function	TAS (3053686)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0009396	folic acid and derivative biosynthetic process	Biological Process	IEA
GO:0009086	methionine biosynthetic process	Biological Process	IEA
GO:0008652	amino acid biosynthetic process	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0006730	one-carbon compound metabolic process	Biological Process	IEA
GO:0006164	purine nucleotide biosynthetic process	Biological Process	IEA
GO:0000105	histidine biosynthetic process	Biological Process	IEA