ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MYH3

Full Name:

myosin, heavy chain 3, skeletal muscle, embryonic

Alias:

HEMHC|MYHC-EMB|MYHSE1|SMHCE

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17p13.1

Physical Location:

10472567-10501339 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 17883 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S1852

10456226

Region:		8456226-12456226
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002470.2	NP_002461.2	NC_000017.9 range: 10472567..10501339, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005863	striated muscle thick filament	Cellular Component	IEA
GO:0016459	myosin complex	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0000146	microfilament motor activity	Molecular Function	NAS (1691980)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005516	calmodulin binding	Molecular Function	IEA
GO:0003779	actin binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0042623	ATPase activity, coupled	Molecular Function	NR
GO:0006941	striated muscle contraction	Biological Process	IEA
GO:0007517	muscle development	Biological Process	TAS (2771643)
GO:0030048	actin filament-based movement	Biological Process	NAS (1691980)