ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NDUFA8

Full Name:

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa

Alias:

CI-19KD|CI-PGIV|MGC793|PGIV

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

9q33.2-q34.11

Physical Location:

123946157-123961918 on NC_000009.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D9S934

2.28

0.0006

120135477

D9S1682

2.33

0.0005

124033322

Region:		120135477-124033322
Phenotype:		ONSET (age at onset of AD)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_014222.2	NP_055037.1	NC_000009.10 range: 123946157..123961918, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	TAS (9860297)
GO:0005747	mitochondrial respiratory chain complex I	Cellular Component	NAS (9878551)
GO:0008137	NADH dehydrogenase (ubiquinone) activity	Molecular Function	NAS (9878551)
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	Biological Process	NAS (9878551)
GO:0006810	transport	Biological Process	IEA