ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NDUFA9

Full Name:

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa

Alias:

MGC111043|NDUFS2L

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12p13.3

Physical Location:

4628543-4666659 on NC_000012.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D12S99

5434815

Region:		3434815-7434815
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005002.3	NP_004993.1	NC_000012.10 range: 4628543..4666659

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031966	mitochondrial membrane	Cellular Component	IDA (17209039)
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005747	mitochondrial respiratory chain complex I	Cellular Component	IDA (9878551\|17209039)
GO:0005759	mitochondrial matrix	Cellular Component	IDA (8486360)
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0008137	NADH dehydrogenase (ubiquinone) activity	Molecular Function	NAS (8486360\|9878551)
GO:0050662	coenzyme binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0003954	NADH dehydrogenase activity	Molecular Function	NAS (8486360)
GO:0003954	NADH dehydrogenase activity	Molecular Function	IMP (11112787)
GO:0006810	transport	Biological Process	IEA
GO:0006814	sodium ion transport	Biological Process	NAS (8486360)
GO:0044237	cellular metabolic process	Biological Process	IEA
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	Biological Process	NAS (9878551)