ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NDUFA10

Full Name:

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa

Alias:

CI-42KD|MGC5103

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q37.3

Physical Location:

240548828-240613470 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S2973

2.20

0.0007

235696080

D2S140

1.95

0.0014

241388318

Region:		235696080-241388318
Phenotype:		WDSFS (withdrawal symptoms factor score)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004544.2	NP_004535.1	NC_000002.10 range: 240548828..240613470, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005747	mitochondrial respiratory chain complex I	Cellular Component	NAS (9878551)
GO:0005759	mitochondrial matrix	Cellular Component	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0008137	NADH dehydrogenase (ubiquinone) activity	Molecular Function	NAS (9878551)
GO:0016773	phosphotransferase activity, alcohol group as acceptor	Molecular Function	IEA
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006091	generation of precursor metabolites and energy	Biological Process	NR
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	Biological Process	NAS (9878551)