ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NDUFS1

Full Name:

NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)

Alias:

CI-75Kd|MGC26839|PRO1304

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q33-q34

Physical Location:

206696047-206732431 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S117

195326948

Region:		195326948-216757195
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005006.5	NP_004997.4	NC_000002.10 range: 206696047..206732431, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005747	mitochondrial respiratory chain complex I	Cellular Component	IMP (16478720)
GO:0005747	mitochondrial respiratory chain complex I	Cellular Component	NAS (9878551)
GO:0005758	mitochondrial intermembrane space	Cellular Component	IDA (15186778)
GO:0003954	NADH dehydrogenase activity	Molecular Function	IEA
GO:0008137	NADH dehydrogenase (ubiquinone) activity	Molecular Function	NAS (9878551)
GO:0008137	NADH dehydrogenase (ubiquinone) activity	Molecular Function	IMP (15824269\|16478720\|16870178)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0051537	2 iron, 2 sulfur cluster binding	Molecular Function	IEA
GO:0051539	4 iron, 4 sulfur cluster binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15186778)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0046034	ATP metabolic process	Biological Process	IMP (15186778)
GO:0045333	cellular respiration	Biological Process	IMP (15186778\|16478720)
GO:0042773	ATP synthesis coupled electron transport	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IDA (15186778)
GO:0006810	transport	Biological Process	IEA
GO:0006800	oxygen and reactive oxygen species metabolic process	Biological Process	IMP (15186778\|16478720\|16870178)
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	Biological Process	NAS (9878551)
GO:0051881	regulation of mitochondrial membrane potential	Biological Process	IMP (15186778\|16478720)