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Gene Information
Gene ID:4719
Full Name:NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
Organism:Homo sapiens (Human)
Genetic Location:2q33-q34
Physical Location:206696047-206732431 on NC_000002.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:BM468661
Fold Change:0.68
P Value:0.01
Tissue:Prefrontal cortex
Dataset Information
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Linkage Dataset
MarkerLODP valueLocation (bp)
D2S117  195326948
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_005006.5NP_004997.4NC_000002.10 range: 206696047..206732431, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentIEA
GO:0005747mitochondrial respiratory chain complex ICellular ComponentIMP (16478720)
GO:0005747mitochondrial respiratory chain complex ICellular ComponentNAS (9878551)
GO:0005758mitochondrial intermembrane spaceCellular ComponentIDA (15186778)
GO:0003954NADH dehydrogenase activityMolecular FunctionIEA
GO:0008137NADH dehydrogenase (ubiquinone) activityMolecular FunctionNAS (9878551)
GO:0008137NADH dehydrogenase (ubiquinone) activityMolecular FunctionIMP (15824269|16478720|16870178)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:00515372 iron, 2 sulfur cluster bindingMolecular FunctionIEA
GO:00515394 iron, 4 sulfur cluster bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (15186778)
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0046034ATP metabolic processBiological ProcessIMP (15186778)
GO:0045333cellular respirationBiological ProcessIMP (15186778|16478720)
GO:0042773ATP synthesis coupled electron transportBiological ProcessIEA
GO:0006915apoptosisBiological ProcessIDA (15186778)
GO:0006810transportBiological ProcessIEA
GO:0006800oxygen and reactive oxygen species metabolic processBiological ProcessIMP (15186778|16478720|16870178)
GO:0006120mitochondrial electron transport, NADH to ubiquinoneBiological ProcessNAS (9878551)
GO:0051881regulation of mitochondrial membrane potentialBiological ProcessIMP (15186778|16478720)
Other Database Cross Links
NCBI Entrez Gene:4719
HuGE Navigator:4719