ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NFX1

Full Name:

nuclear transcription factor, X-box binding 1

Alias:

DKFZp779G2416|MGC20369|NFX2

Organism:

Homo sapiens (Human)

Chromosome:

9

Genetic Location:

9p13.3

Physical Location:

33280509-33361154 on NC_000009.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U15306
Fold Change:		1.4, 1.4
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002504.3	NP_002495.2	NC_000009.10 range: 33280509..33361154
NM_147133.1	NP_667344.1	NC_000009.10 range: 33280509..33361154
NM_147134.1	NP_667345.1	NC_000009.10 range: 33280509..33361154

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	TAS (7964459)
GO:0005515	protein binding	Molecular Function	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0006954	inflammatory response	Biological Process	TAS (7964459)
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (7964459)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000086102

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: