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Gene Information
Gene ID:48
Full Name:aconitase 1, soluble
Organism:Homo sapiens (Human)
Genetic Location:9p22-q32|9p21.1
Physical Location:32374649-32440829 on NC_000009.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AA114871
Fold Change:0.67
P Value:5.00E-03
Tissue:Prefrontal cortex
Dataset Information
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Gene Information
Original ID1:ACO1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002197.2NP_002188.1NC_000009.10 range: 32374649..32440829
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentIDA (16527810)
GO:0005737cytoplasmCellular ComponentNAS (1738601)
GO:0005783endoplasmic reticulumCellular ComponentIDA (16144863)
GO:0005794Golgi apparatusCellular ComponentIDA (16144863)
GO:0051536iron-sulfur cluster bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0016829lyase activityMolecular FunctionIEA
GO:0003723RNA bindingMolecular FunctionIDA (1946430)
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0003994aconitate hydratase activityMolecular FunctionIDA (1946430)
GO:0003723RNA bindingMolecular FunctionNAS (1903202)
GO:00515394 iron, 4 sulfur cluster bindingMolecular FunctionIEA
GO:0006099tricarboxylic acid cycleBiological ProcessIEA
GO:0006101citrate metabolic processBiological ProcessIDA (16527810)
GO:0008152metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:48
HuGE Navigator:48