ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ACO1

Full Name:

aconitase 1, soluble

Alias:

ACONS|IREB1|IREBP|IREBP1|IRP1

Organism:

Homo sapiens (Human)

Chromosome:

9

Genetic Location:

9p22-q32|9p21.1

Physical Location:

32374649-32440829 on NC_000009.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AA114871
Fold Change:		0.67
P Value:		5.00E-03
Tissue:		Prefrontal cortex

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Information

Original ID1:

ACO1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002197.2	NP_002188.1	NC_000009.10 range: 32374649..32440829

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	IDA (16527810)
GO:0005737	cytoplasm	Cellular Component	NAS (1738601)
GO:0005783	endoplasmic reticulum	Cellular Component	IDA (16144863)
GO:0005794	Golgi apparatus	Cellular Component	IDA (16144863)
GO:0051536	iron-sulfur cluster binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0016829	lyase activity	Molecular Function	IEA
GO:0003723	RNA binding	Molecular Function	IDA (1946430)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0003994	aconitate hydratase activity	Molecular Function	IDA (1946430)
GO:0003723	RNA binding	Molecular Function	NAS (1903202)
GO:0051539	4 iron, 4 sulfur cluster binding	Molecular Function	IEA
GO:0006099	tricarboxylic acid cycle	Biological Process	IEA
GO:0006101	citrate metabolic process	Biological Process	IDA (16527810)
GO:0008152	metabolic process	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000122729

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: