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Gene Information
Gene ID:4846
Symbol:NOS3
Full Name:nitric oxide synthase 3 (endothelial cell)
Alias:ECNOS|NOS III|eNOS
Organism:Homo sapiens (Human)
Chromosome:7
Genetic Location:7q36
Physical Location:150319079-150342608 on NC_000007.12
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:NOS3
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
NOS31Alcohol-Induced Disorders
NOS31Alcoholism
NOS31Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000603.3NP_000594.2NC_000007.12 range: 150319079..150342608
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000139Golgi membraneCellular ComponentEXP (9188442|9580552|10781589|11149895|16722822|16807357)
GO:0005901caveolaCellular ComponentIDA (17848177)
GO:0005856cytoskeletonCellular ComponentIEA
GO:0005829cytosolCellular ComponentEXP (7512951|10559837)
GO:0005794Golgi apparatusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentTAS (9794441)
GO:0016020membraneCellular ComponentIEA
GO:0010181FMN bindingMolecular FunctionIEA
GO:0020037heme bindingMolecular FunctionIEA
GO:0050660FAD bindingMolecular FunctionIEA
GO:0009055electron carrier activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0050661NADP bindingMolecular FunctionIEA
GO:0005516calmodulin bindingMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0004517nitric-oxide synthase activityMolecular FunctionTAS (10376603)
GO:0006928cell motilityBiological ProcessTAS (8999856)
GO:0006809nitric oxide biosynthetic processBiological ProcessIEA
GO:0006520amino acid metabolic processBiological ProcessNR
Other Database Cross Links
NCBI Entrez Gene:4846
HGNC:7876
Ensembl:ENSG00000164867
MIM:163729
HPRD:01224
HuGE Navigator:4846
dbSNP:NOS3
GeneCard:NOS3
AceView:NOS3