ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NSF

Full Name:

N-ethylmaleimide-sensitive factor

Alias:

SKD2

Organism:

Homo sapiens (Human)

Chromosome:

17

Genetic Location:

17q21

Physical Location:

42023353-42189999 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U03985
Fold Change:		1.6, 1.4
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Information

Original ID1:

NSF

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006178.2	NP_006169.2	NC_000017.9 range: 42023353..42189999

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0017111	nucleoside-triphosphatase activity	Molecular Function	IEA
GO:0015031	protein transport	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000073969

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: