| Gene Information |
| Gene ID: | | 497770 |
| Symbol: | | Scn3a |
| Full Name: | | sodium channel, voltage-gated, type III, alpha |
| Alias: | | Nav1.3|SCIII |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 3 |
| Genetic Location: | | 3q21 |
| Physical Location: | | 47421320-47543605 on NC_005102.2, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 6328 Symbol (Name): SCN3A (sodium channel, voltage-gated, type III, alpha subunit) |
| Ortholog Status: | | The human GeneID 6328 is not in current human dataset. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Scn3a | | Fold Change: | | -1.38 | | Tissue: | | Accumbens |
| | Gene Information | | Original ID1: | | Scn3a | | Fold Change: | | -1.44 | | Tissue: | | Amygdala |
| | Gene Information | | Original ID1: | | Scn3a | | Fold Change: | | -1.39 | | Tissue: | | Frontalcortex |
| | Gene Information | | Original ID1: | | Scn3a | | Fold Change: | | -1.46 | | Tissue: | | Caudate-putamen |
| | Dataset Information | | Name: | | 17517326 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed | | Summary: | | The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0001518 | voltage-gated sodium channel complex | Cellular Component | IDA (15664695) | |
| GO:0001518 | voltage-gated sodium channel complex | Cellular Component | IEA | |
| GO:0001518 | voltage-gated sodium channel complex | Cellular Component | TAS (14523090) | |
| GO:0016021 | integral to membrane | Cellular Component | IEA | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0005624 | membrane fraction | Cellular Component | ISS | |
| GO:0005737 | cytoplasm | Cellular Component | ISS | |
| GO:0031402 | sodium ion binding | Molecular Function | IDA (15664695) | |
| GO:0031402 | sodium ion binding | Molecular Function | IEA | |
| GO:0005248 | voltage-gated sodium channel activity | Molecular Function | TAS (14523090) | |
| GO:0005248 | voltage-gated sodium channel activity | Molecular Function | IEA | |
| GO:0005248 | voltage-gated sodium channel activity | Molecular Function | IDA (15664695) | |
| GO:0005244 | voltage-gated ion channel activity | Molecular Function | IEA | |
| GO:0006814 | sodium ion transport | Biological Process | IEA | |
| GO:0009611 | response to wounding | Biological Process | IEP (14523090) | |
| GO:0019228 | regulation of action potential in neuron | Biological Process | IDA (15664695) | |
| GO:0019233 | sensory perception of pain | Biological Process | IMP (14523090) | |
| GO:0006811 | ion transport | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 497770 |
| RGD: | | 3635 |
| Ensembl: | | ENSRNOG00000005007 |
| dbSNP: | | Scn3a |
