Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:4999
Symbol:ORC2L
Full Name:origin recognition complex, subunit 2-like (yeast)
Alias:ORC2
Organism:Homo sapiens (Human)
Chromosome:2
Genetic Location:2q33
Physical Location:201483138-201536654 on NC_000002.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D2S117  195326948
Region:195326948-216757195
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_006190.3NP_006181.1NC_000002.10 range: 201483138..201536654, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000808origin recognition complexCellular ComponentIEA
GO:0005634nucleusCellular ComponentTAS (8808289)
GO:0005654nucleoplasmCellular ComponentEXP (10436018|11095689|11125146|11931757|12045100|15226314|15684404|15707391)
GO:0003688DNA replication origin bindingMolecular FunctionTAS (8808289)
GO:0005515protein bindingMolecular FunctionIPI (11095689)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessTAS (8808289)
GO:0006260DNA replicationBiological ProcessEXP (12791985)
GO:0006260DNA replicationBiological ProcessIEA
GO:0006270DNA replication initiationBiological ProcessTAS (8808289)
Other Database Cross Links
NCBI Entrez Gene:4999
HGNC:8488
Ensembl:ENSG00000115942
MIM:601182
HPRD:03112
HuGE Navigator:4999
dbSNP:ORC2L
GeneCard:ORC2L
AceView:ORC2L