ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

FURIN

Full Name:

furin (paired basic amino acid cleaving enzyme)

Alias:

FUR|PACE|PCSK3|SPC1

Organism:

Homo sapiens (Human)

Chromosome:

15

Genetic Location:

15q26.1

Physical Location:

89212888-89227690 on NC_000015.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

FURIN

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002569.2	NP_002560.1	NC_000015.8 range: 89212888..89227690

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	EXP (8615794)
GO:0030140	trans-Golgi network transport vesicle	Cellular Component	IDA (15078902)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0009986	cell surface	Cellular Component	IDA (16537537)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005802	trans-Golgi network	Cellular Component	IDA (14744861)
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IDA (10567353)
GO:0048406	nerve growth factor binding	Molecular Function	IDA (8615794)
GO:0002020	protease binding	Molecular Function	IPI (14744861)
GO:0016808	proprotein convertase activity	Molecular Function	IDA (8615794)
GO:0004276	furin activity	Molecular Function	IDA (15082773)
GO:0004289	subtilase activity	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0004867	serine-type endopeptidase inhibitor activity	Molecular Function	IDA (10567353)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0051605	protein maturation via proteolysis	Biological Process	IDA (10567353\|14744861)
GO:0051605	protein maturation via proteolysis	Biological Process	IMP (15899807)
GO:0043043	peptide biosynthetic process	Biological Process	IDA (8262946)
GO:0042176	regulation of protein catabolic process	Biological Process	IMP (15899807)
GO:0032911	negative regulation of transforming growth factor-beta1 production	Biological Process	IMP (15899807)
GO:0032904	negative regulation of nerve growth factor production	Biological Process	IDA (10567353)
GO:0032804	negative regulation of low-density lipoprotein receptor catabolic process	Biological Process	IDA (16912035)
GO:0032455	nerve growth factor processing	Biological Process	EXP (12787574)
GO:0008283	cell proliferation	Biological Process	IMP (15899807)
GO:0006465	signal peptide processing	Biological Process	IDA (16912035)
GO:0052548	regulation of endopeptidase activity	Biological Process	IDA (14744861)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000140564

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: