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Gene Information
Gene ID:5046
Symbol:PCSK6
Full Name:proprotein convertase subtilisin/kexin type 6
Alias:PACE4|SPC4
Organism:Homo sapiens (Human)
Chromosome:15
Genetic Location:15q26.3
Physical Location:99661655-99847709 on NC_000015.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:D87993
Fold Change:-1.9, -2.1
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002570.3NP_002561.1NC_000015.8 range: 99661655..99847709, complement
NM_138319.2NP_612192.1NC_000015.8 range: 99661655..99847709, complement
NM_138320.1NP_612193.1NC_000015.8 range: 99661655..99847709, complement
NM_138321.1NP_612194.1NC_000015.8 range: 99661655..99847709, complement
NM_138322.2NP_612195.1NC_000015.8 range: 99661655..99847709, complement
NM_138323.1NP_612196.1NC_000015.8 range: 99661655..99847709, complement
NM_138324.1NP_612197.1NC_000015.8 range: 99661655..99847709, complement
NM_138325.2NP_612198.2NC_000015.8 range: 99661655..99847709, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0009986cell surfaceCellular ComponentIDA (12535616)
GO:0016020membraneCellular ComponentIEA
GO:0031012extracellular matrixCellular ComponentIDA (12535616)
GO:0005796Golgi lumenCellular ComponentEXP (8615794)
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005625soluble fractionCellular ComponentIDA (8218226)
GO:0005622intracellularCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentIDA (8906861)
GO:0005576extracellular regionCellular ComponentIEA
GO:0043499eukaryotic cell surface bindingMolecular FunctionIDA (12535616)
GO:0016808proprotein convertase activityMolecular FunctionIDA (8615794|8906861)
GO:0048406nerve growth factor bindingMolecular FunctionIDA (8615794)
GO:0004289subtilase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0008233peptidase activityMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0008201heparin bindingMolecular FunctionIDA (12535616)
GO:0009100glycoprotein metabolic processBiological ProcessIDA (8218226)
GO:0006508proteolysisBiological ProcessIEA
GO:0032902nerve growth factor productionBiological ProcessIDA (8615794)
GO:0032455nerve growth factor processingBiological ProcessEXP (12787574)
GO:0030510regulation of BMP signaling pathwayBiological ProcessTAS (10467177)
GO:0051605protein maturation via proteolysisBiological ProcessIDA (8218226|9738469)
Other Database Cross Links
NCBI Entrez Gene:5046
HGNC:8569
Ensembl:ENSG00000140479
MIM:167405
HPRD:01329
HuGE Navigator:5046
dbSNP:PCSK6
GeneCard:PCSK6
AceView:PCSK6