ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PAFAH1B1

Full Name:

platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa

Alias:

LIS1|LIS2|MDCR|MDS|PAFAH

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17p13.3

Physical Location:

2443685-2535637 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		L13385
Fold Change:		1.4, 1.5
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000430.3	NP_000421.1	NC_000017.9 range: 2443685..2535637

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005874	microtubule	Cellular Component	IEA
GO:0031965	nuclear membrane	Cellular Component	IEA
GO:0005938	cell cortex	Cellular Component	IDA (11940666)
GO:0005875	microtubule associated complex	Cellular Component	IDA (11889140)
GO:0016020	membrane	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005819	spindle	Cellular Component	IEA
GO:0005813	centrosome	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0000776	kinetochore	Cellular Component	IDA (11056532\|11889140\|11940666)
GO:0000235	astral microtubule	Cellular Component	IDA (11940666)
GO:0045502	dynein binding	Molecular Function	IDA (11889140)
GO:0016042	lipid catabolic process	Biological Process	IEA
GO:0030154	cell differentiation	Biological Process	IEA
GO:0000132	establishment of mitotic spindle orientation	Biological Process	IMP (11056532)
GO:0007399	nervous system development	Biological Process	TAS (9063735)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	TAS (8355785)
GO:0007067	mitosis	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0007017	microtubule-based process	Biological Process	IDA (11940666)
GO:0006928	cell motility	Biological Process	TAS (9063735)
GO:0006810	transport	Biological Process	IEA
GO:0051301	cell division	Biological Process	IEA