ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NOX4

Full Name:

NADPH oxidase 4

Alias:

KOX|KOX-1|RENOX

Organism:

Homo sapiens (Human)

Chromosome:

11

Genetic Location:

11q14.2-q21

Physical Location:

88699159-88864300 on NC_000011.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

NOX4

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016931.2	NP_058627.1	NC_000011.8 range: 88699159..88864300, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	TAS (10869423)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	TAS (10869423)
GO:0009055	electron carrier activity	Molecular Function	TAS (10869423)
GO:0019826	oxygen sensor activity	Molecular Function	TAS (10869423)
GO:0020037	heme binding	Molecular Function	TAS (10869423)
GO:0016174	NAD(P)H oxidase activity	Molecular Function	TAS (10869423)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0050660	FAD binding	Molecular Function	TAS (10869423)
GO:0042554	superoxide release	Biological Process	ISS (10869423)
GO:0008285	negative regulation of cell proliferation	Biological Process	ISS (10869423)
GO:0007569	cell aging	Biological Process	ISS (10869423)
GO:0006954	inflammatory response	Biological Process	TAS (10869423)
GO:0006800	oxygen and reactive oxygen species metabolic process	Biological Process	IDA (10869423)
GO:0000902	cell morphogenesis	Biological Process	ISS (10869423)
GO:0055114	oxidation reduction	Biological Process	IDA (10869423)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000086991

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: