Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:5105
Symbol:PCK1
Full Name:phosphoenolpyruvate carboxykinase 1 (soluble)
Alias:MGC22652|PEPCK-C|PEPCK1|PEPCKC
Organism:Homo sapiens (Human)
Chromosome:20
Genetic Location:20q13.31
Physical Location:55569542-55574921 on NC_000020.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:PCK1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original ID1:R86197
Fold Change:1.6
P Value:0.05
Tissue:Nucleus accumbens
Dataset Information
Name:15816859
Method:Microarray
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002591.3NP_002582.3NC_000020.9 range: 55569542..55574921
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (11851336)
GO:0005737cytoplasmCellular ComponentIEA
GO:0017076purine nucleotide bindingMolecular FunctionIEA
GO:0016829lyase activityMolecular FunctionIEA
GO:0031406carboxylic acid bindingMolecular FunctionIDA (11851336)
GO:0000287magnesium ion bindingMolecular FunctionIDA (11851336)
GO:0005525GTP bindingMolecular FunctionIEA
GO:0004613phosphoenolpyruvate carboxykinase (GTP) activityMolecular FunctionIEA
GO:0004613phosphoenolpyruvate carboxykinase (GTP) activityMolecular FunctionEXP (11851336)
GO:0030145manganese ion bindingMolecular FunctionIDA (11851336)
GO:0006094gluconeogenesisBiological ProcessIEA
GO:0032868response to insulin stimulusBiological ProcessIDA (14764811)
Other Database Cross Links
NCBI Entrez Gene:5105
HGNC:8724
Ensembl:ENSG00000124253
MIM:261680
HPRD:02028
HuGE Navigator:5105
dbSNP:PCK1
GeneCard:PCK1
AceView:PCK1