ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ING4

Full Name:

inhibitor of growth family, member 4

Alias:

MGC12557|my036|p29ING4

Organism:

Homo sapiens (Human)

Chromosome:

12

Genetic Location:

12p13.31

Physical Location:

6629706-6642564 on NC_000012.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D12S99

5434815

Region:		3434815-7434815
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016162.3	NP_057246.2	NC_000012.10 range: 6629706..6642564, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (15029197)
GO:0005515	protein binding	Molecular Function	IPI (12750254\|15029197)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006915	apoptosis	Biological Process	IDA (15251430)
GO:0007050	cell cycle arrest	Biological Process	IDA (15251430)
GO:0006473	protein amino acid acetylation	Biological Process	IDA (12750254)
GO:0008285	negative regulation of cell proliferation	Biological Process	IDA (12750254\|15251430)
GO:0045786	negative regulation of cell cycle	Biological Process	IEA
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA (15029197)
GO:0045926	negative regulation of growth	Biological Process	IDA (12750254)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000111653

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: