ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RAPGEFL1

Full Name:

Rap guanine nucleotide exchange factor (GEF)-like 1

Alias:

Link-GEFII|MGC134798|MGC134799

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q21.1-q21.2

Physical Location:

35591393-35605425 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AA707689
Fold Change:		1.5, 1.7
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016339.3	NP_057423.1	NC_000017.9 range: 35591393..35605425

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	TAS (9582122)
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	TAS (9582122)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (9582122)
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0007399	nervous system development	Biological Process	TAS (9789079)