ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TLR7

Full Name:

toll-like receptor 7

Organism:

Homo sapiens (Human)

Chromosome:

X

Genetic Location:

Xp22.3

Physical Location:

12795122-12818400 on NC_000023.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

TLR7

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016562.3	NP_057646.1	NC_000023.9 range: 12795122..12818400

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0010008	endosome membrane	Cellular Component	EXP (14625308\|16024789)
GO:0035197	siRNA binding	Molecular Function	ISS
GO:0003725	double-stranded RNA binding	Molecular Function	IDA (16111635)
GO:0005515	protein binding	Molecular Function	IEA
GO:0004888	transmembrane receptor activity	Molecular Function	IEA
GO:0003727	single-stranded RNA binding	Molecular Function	ISS
GO:0007165	signal transduction	Biological Process	IEA
GO:0045416	positive regulation of interleukin-8 biosynthetic process	Biological Process	IMP (16188996)
GO:0045359	positive regulation of interferon-beta biosynthetic process	Biological Process	IDA (16286015)
GO:0045356	positive regulation of interferon-alpha biosynthetic process	Biological Process	IDA (16286015)
GO:0045087	innate immune response	Biological Process	IEA
GO:0045078	positive regulation of interferon-gamma biosynthetic process	Biological Process	IDA (16286015)
GO:0006954	inflammatory response	Biological Process	IEA
GO:0007249	I-kappaB kinase/NF-kappaB cascade	Biological Process	EXP (15276183)
GO:0051607	defense response to virus	Biological Process	IMP (16188996)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000196664

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: