ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TNFRSF12A

Full Name:

tumor necrosis factor receptor superfamily, member 12A

Alias:

CD266|FN14|TWEAKR

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

16p13.3

Physical Location:

3010360-3012384 on NC_000016.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI827127
Fold Change:		1.8, 1.4
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016639.2	NP_057723.1	NC_000016.8 range: 3010360..3012384

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0001525	angiogenesis	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	TAS (10551889)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0006928	cell motility	Biological Process	TAS (10551889)
GO:0006915	apoptosis	Biological Process	IEA
GO:0030154	cell differentiation	Biological Process	IEA