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Gene Information
Gene ID:51426
Symbol:POLK
Full Name:polymerase (DNA directed) kappa
Alias:DINB1|DINP|POLQ
Organism:Homo sapiens (Human)
Chromosome:5
Genetic Location:5q13
Physical Location:74843336-74930888 on NC_000005.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:POLK
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D5S647  66282906
Region:66282906-76193808
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_016218.1NP_057302.1NC_000005.8 range: 74843336..74930888
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0016779nucleotidyltransferase activityMolecular FunctionIEA
GO:0003887DNA-directed DNA polymerase activityMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionIEA
GO:0006260DNA replicationBiological ProcessIEA
GO:0006281DNA repairBiological ProcessIEA
GO:0006280mutagenesisBiological ProcessTAS (10620008)
Other Database Cross Links
NCBI Entrez Gene:51426
HGNC:9183
Ensembl:ENSG00000122008
MIM:605650
HPRD:09291
HuGE Navigator:51426
dbSNP:POLK
GeneCard:POLK
AceView:POLK