ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

POLK

Full Name:

polymerase (DNA directed) kappa

Alias:

DINB1|DINP|POLQ

Organism:

Homo sapiens (Human)

Chromosome:

5

Genetic Location:

5q13

Physical Location:

74843336-74930888 on NC_000005.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

POLK

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D5S647

66282906

Region:		66282906-76193808
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016218.1	NP_057302.1	NC_000005.8 range: 74843336..74930888

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0016779	nucleotidyltransferase activity	Molecular Function	IEA
GO:0003887	DNA-directed DNA polymerase activity	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0006260	DNA replication	Biological Process	IEA
GO:0006281	DNA repair	Biological Process	IEA
GO:0006280	mutagenesis	Biological Process	TAS (10620008)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000122008

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: