ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ANAPC11

Full Name:

APC11 anaphase promoting complex subunit 11 homolog (yeast)

Alias:

APC11|Apc11p|HSPC214|MGC882

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q25.3

Physical Location:

77442894-77451654 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S928

77846128

Region:		75846128-78774742
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0005654	nucleoplasm	Cellular Component	EXP (10548110\|11340163\|15029244)
GO:0005680	anaphase-promoting complex	Cellular Component	IDA (11739784)
GO:0005829	cytosol	Cellular Component	EXP (10793135\|11285280\|11535616\|11742988\|12070128)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA (11739784)
GO:0005515	protein binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0051436	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (14593737\|15029244)
GO:0051301	cell division	Biological Process	IEA
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	EXP (11285280)
GO:0016567	protein ubiquitination	Biological Process	IDA (11739784)
GO:0007067	mitosis	Biological Process	TAS (11739784)
GO:0007049	cell cycle	Biological Process	IEA
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (10793135)