ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SIRT7

Full Name:

sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)

Alias:

MGC126840|MGC126842|SIR2L7

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q25

Physical Location:

77463106-77469331 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S928

77846128

Region:		75846128-78774742
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016538.1	NP_057622.1	NC_000017.9 range: 77463106..77469331, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005677	chromatin silencing complex	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0017136	NAD-dependent histone deacetylase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0051287	NAD binding	Molecular Function	IEA
GO:0005507	copper ion binding	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0004735	pyrroline-5-carboxylate reductase activity	Molecular Function	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006561	proline biosynthetic process	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0006342	chromatin silencing	Biological Process	IEA
GO:0006476	protein amino acid deacetylation	Biological Process	IEA