ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

RAB14

Full Name:

RAB14, member RAS oncogene family

Alias:

FBP|RAB-14

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

9q32-q34.11

Physical Location:

122980236-123003912 on NC_000009.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 68365 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D9S934

2.28

0.0006

120135477

D9S1682

2.33

0.0005

124033322

Region:		120135477-124033322
Phenotype:		ONSET (age at onset of AD)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016322.2	NP_057406.2	NC_000009.10 range: 122980236..123003912, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0048471	perinuclear region of cytoplasm	Cellular Component	ISS
GO:0042175	nuclear envelope-endoplasmic reticulum network	Cellular Component	ISS
GO:0030140	trans-Golgi network transport vesicle	Cellular Component	ISS
GO:0005886	plasma membrane	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	ISS
GO:0005795	Golgi stack	Cellular Component	ISS
GO:0005791	rough endoplasmic reticulum	Cellular Component	ISS
GO:0005770	late endosome	Cellular Component	ISS
GO:0005769	early endosome	Cellular Component	ISS
GO:0005764	lysosome	Cellular Component	ISS
GO:0005624	membrane fraction	Cellular Component	ISS
GO:0005622	intracellular	Cellular Component	IDA (11256614)
GO:0003924	GTPase activity	Molecular Function	NAS (15004230)
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0007264	small GTPase mediated signal transduction	Biological Process	NAS
GO:0015031	protein transport	Biological Process	IEA
GO:0016192	vesicle-mediated transport	Biological Process	NAS (15004230)
GO:0006895	Golgi to endosome transport	Biological Process	TAS (15004230)
GO:0046907	intracellular transport	Biological Process	NAS (15004230)
GO:0007269	neurotransmitter secretion	Biological Process	NAS