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Gene Information
Gene ID:51741
Symbol:WWOX
Full Name:WW domain containing oxidoreductase
Alias:D16S432E|FOR|FRA16D|HHCMA56|PRO0128|WOX1|WWOX v8
Organism:Homo sapiens (Human)
Chromosome:16
Genetic Location:16q23.3-q24.1
Physical Location:76691051-77804064 on NC_000016.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:WWOX
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D16S516  77681517
Region:75681517-79681517
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_016373.1NP_057457.1NC_000016.8 range: 76691051..77804064
NM_130791.1NP_570607.1NC_000016.8 range: 76691051..77804064
NM_130844.1NP_570859.1NC_000016.8 range: 76691051..77804064
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentTAS (10786676)
GO:0005739mitochondrionCellular ComponentIEA
GO:0005794Golgi apparatusCellular ComponentIDA (15064722)
GO:0005488bindingMolecular FunctionIEA
GO:0050662coenzyme bindingMolecular FunctionTAS (10786676)
GO:0046983protein dimerization activityMolecular FunctionTAS (10786676)
GO:0016491oxidoreductase activityMolecular FunctionTAS (10786676)
GO:0016491oxidoreductase activityMolecular FunctionNAS (10861292)
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0045786negative regulation of cell cycleBiological ProcessIEA
GO:0008202steroid metabolic processBiological ProcessTAS (10786676)
GO:0008152metabolic processBiological ProcessIEA
GO:0055114oxidation reductionBiological ProcessTAS (10786676)
Other Database Cross Links
NCBI Entrez Gene:51741
HGNC:12799
Ensembl:ENSG00000186153
MIM:605131
HPRD:05501
HuGE Navigator:51741
dbSNP:WWOX
GeneCard:WWOX
AceView:WWOX