ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SERPINF1

Full Name:

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

Alias:

EPC-1|PEDF|PIG35

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17p13.1

Physical Location:

1612008-1627617 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U29953
Fold Change:		1.6, 1.4
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002615.4	NP_002606.3	NC_000017.9 range: 1612008..1627617

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IDA (12737624)
GO:0042470	melanosome	Cellular Component	IEA
GO:0004867	serine-type endopeptidase inhibitor activity	Molecular Function	TAS (8473338)
GO:0007275	multicellular organismal development	Biological Process	TAS (8473338)
GO:0008283	cell proliferation	Biological Process	TAS (8473338)
GO:0016525	negative regulation of angiogenesis	Biological Process	IDA (11562499)
GO:0050769	positive regulation of neurogenesis	Biological Process	IDA (8226833)